Developed based on a thorough review of the scientific evidence, NutraOrigin’s Thinex formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how this product helps you lose weight. *
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Conjugated Linoleic Acid
Conjugated linoleic acid (CLA) is a fatty acid that occurs naturally in milk, cheese and meat. CLA has been the subject of numerous human clinical trials. While results have been mixed, a recent meta-analysis — which reviewed the results of 18 previous randomized, double-blind placebo-controlled studies — found that CLA may cause modest, short-term loss of body fat.* Supplementation with CLA caused, on average, a loss of 0.2 pounds of body fat per week compared to placebo.* (1)
5-hyroxytrytophan
5-hydroxytryptophan (5-HTP) is an amino acid used in the formation of serotonin, a brain chemical that regulates appetite.* Interestingly, when people diet, their levels of serotonin tend to plummet, which may explain why they experience intense carbohydrate cravings and have a tendency toward binge eating. (2) By increasing serotonin levels, 5-HTP is theorized to result in decreased food intake and weight loss.* In fact, three different human clinical trials in overweight individuals have shown that supplementation with 5-HTP causes overweight individuals to eat less and shed pounds.* (3,4,5)
Caralluma Fimbriata
Caralluma fimbriata is an edible cactus that has been used traditionally in India to dull the sensation of hunger and boost endurance.* One placebo-controlled randomized study assessed the effect of caralluma extract on overweight individuals. Those receiving Caralluma fimbriata showed significant declines in waist circumference and hunger levels compared to those taking placebo.* (6)
Gymnema Sylvestre
Gymnema sylvestre is an Indian herb whose history goes back 2,000 years. Both animal and human research on gymnema is very encouraging. The herb has been shown to balance blood sugar, positively impact fat metabolism and suppress body weight in animals.* (7,8,9,10,11,12) Two human clinical trials have confirmed gymenma’s blood sugar balancing and fat metabolizing effects. (13,14) It appears to enhance the body’s production of insulin.* (14)
Fucoxanthin
Humans have two main kinds of fat — white adipose tissue (WAT) and brown adipose tissue (BAT). Interestingly, brown fat is actually beneficial, because it contains a key molecule needed for thermogenesis called UCP1. Of course, most fat in the body is of the white variety.
Fucoxanthin is a seaweed extract that has been shown in multiple animal studies to increase the expression of UCP1 in the WAT, which may lower the amount of WAT in the body.* (15,16,17)
7-keto DHEA
7-keto DHEA is a natural metabolite, or end product, of the steroidal hormone DHEA. As you age, your production of DHEA, the most abundant steroid in the body, decreases.
Supplementation with 7-keto DHEA results in significant weight loss in overweight individuals, according to one randomized, double-blind placebo-controlled study.* Thirty overweight adults were randomly assigned to take either 7-keto DHEA or placebo for eight weeks. Both groups followed an 1800-calorie diet and participated in regular exercise. At the end of the trial, the 7-keto group had lost 6.3 pounds — three times the amount (2.1 pounds) of those taking placebo.* (18) 7-keto may work by boosting thyroid function, leading to a reduction of fat and weight.* (18) It may also induce thermogenic enzymes that speed up metabolic rate.* (19)
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- Whigham LD, Watras AC, Schoeller DA. "Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans." Am J Clin Nutr (2007) 85: 1203-1211.
- Birdsall TC. "5-Hydroxytryptophan: A clinically-effective serotonin precursor." Altern Med Rev. 1998;3(4):271-80.
- Ceci F, et al. "The effects of oral 5-hyroxytrytophan administration on feeding behavior in obese adult female subjects." J Neural Transmit (1989) 76: 109-117.
- Cangiano C, et al. "Effects of 5-hyroxytrytophan on eating behavior and adherence to dietary prescription in obese adult subjects." Adv Exp Med Biol (1991) 294: 591-593.
- Cangiano C, et al. "Eating behavior and adherence to dietary prescription in obese adult subjects treated with 5-hyroxytrytophan." Am J Clin Nutr (1992) 56: 863-867.
- Kuriyan R, et al. "Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women." Appetite. 2007 May; 48(3): 338-44.
- Srivastava Y, et al. "Hypoglycemic and Life-prolonging Properties of Gymnema sylvestre Leaf Extract in Diabetic Rats." Isr J Med Sci. (1985) Jun; 21(6): 540-42.
- Okabayashi Y, et al. "Effect of Gymnema sylvestre, R.Br. On Glucose Homeostasis in Rats." Diabetes Res Clin Pract. (1990) May; 9(2): 143-48.
- Preuss HG, et al. "Comparative Effects of Chromium, Vanadium and Gymnema sylvestre on Sugar-Induced Blood Pressure Elevations in SHR." J Am Coll Nutr (1998) April; 17(2): 116-23.
- Murakami N, Murakami T, and Kadoya M. "New hypoglycemic constituents in 'gymnemic acid' from Gymnema sylvestre." Chem Pharm Bull (1996) 44: 469-471.Close window
- Shigematsu N, Asano R, and Okazaki M. "Effect of administration with the extract of Gymnema sylvestre leaves on lipid metabolism in rats." Biol Pharm Bull (2001) 24: 713-717.
- Shigematsu N, et al. "Effect of long-term administration with Gymnema sylvestre R. BR on plasma and liver lipid in rats." Biol Pharm Bull. 2001 Jun;24(6):643-9.
- Baskaran N, et al. "Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients." J Ethnopharmacol. 1990 Oct;30(3):295-300.
- Shanmugasundaram ER, et al. "Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus." J Ethnopharmacol. 1990 Oct;30(3):281-94.
- Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. "Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues." Biochem Biophys Res Commun (2005) July; 332(2): 392-7.
- Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. "Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin." J Oleo Sci (2007) 56.12: 615-621.
- Maeda H, Hosokawa M, Sashima T, Miyashita K. "Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice." J Agric Food Chem (2007) 55.19: 7701-7706.
- Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Therap Res. 2000;61(7):435-42.
- Lardy H, Partridge B, Kneer N, Wei Y. "Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone." Proc Natl Acad Sci USA (1995) Jul; 92(14): 6617-9.
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