Developed based on a thorough review of the scientific evidence, NutraOrigin’s Cognigin formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how this product supports healthy brain function and mental sharrpness.*

Ashwagandha extract
Ashwaganda is an Indian herb that plays a central role in the herbal tradition of Ayurveda. Several animal studies have found that ashwagandha extract helps preserve memory.* (1,2,3,4,5) One study demonstrated that the herb caused an increase in the receptor capacity of acetylcholine, a key brain chemical involved in memory and learning.* (6) Another found it was able to protect brain cells from stress-induced harm.* (7)

Animals studies have also consistently found that ashwagandha combats the effects of occasional stress and generally promotes wellness.* (8,9,10,11) Additionally, ashwagandha offers potent antioxidant protection from harmful free radicals.* (12,13)

Bacopa extract
Bacopa is another herb that hails from the Ayurvedic tradition. Two double-blind, placebo-controlled human clinical trials have demonstrated bacopa’s brain benefits.* The first found bacopa maintains speed of visual information processing, learning rate and memory consolidation, while the second showed the herb supports the retention of new information.* (14,15) Bacopa is also considered as an antioxidant with the capabilities to scavenge free radicals. (16) *

Eleuthero root
Eleuthero is a classic adaptogenic herb, meaning it helps the body to adapt to various kinds of stress.* Human studies show eleuthero may increase work capacity and maintain mental alertness without the crash that comes with caffeinated products. (17,18,19) Eleuthero can also neutralize free radicals and accelerate lipid mobilization, thus exerting a cellular protective effect. (20,21) *

Ginkgo extract
Ginkgo is probably the most renowned herb for supporting brain function.* Many controlled human clinical trials have shown that ginkgo extract supports healthy memory, cognitive function and orientation.* (22) It also reduces occasional fatigue and stress.* A powerful antioxidant (23), ginkgo extract is believed to work by enhancing circulation to the brain and inhibiting blood clots.* (22)

Vinpocetine

Vinpocetine is synthesized from vincamine, a compound found in the leaves of the periwinkle plant. A review of three double-blind, placebo-controlled randomized studies on vinpocetine, totaling 583 people, found the compound benefits cognition.* (24) Vinpocetine has also been shown to support memory in normal healthy adults (25) and exert antioxidant effects protecting nerve cells from harmful free radicals.* (26)

Alpha-lipoic acid

Alpha-lipoic acid is a naturally occurring compound that acts a potent free-radical scavenger. It has the unique ability to function in both water and fat, making it extremely versatile as an antioxidant. Animal research has shown that alpha-lipoic acid helps preserve spatial memory (27) and protect against cerebral oxidative stress.* (28,29) Alpha-lipoic acid may also enhance mitochondrial and cognitive function.* (30,31)

Citicoline
Citicoline, also known as cytidine 5'-diphosphocholine or CDP-choline, is essential for the synthesis of cell membrane phospholipids such as phosphatidylcholine. Following oral administration, citicoline is able to penetrate the blood-brain-barrier, where it is incorporated into the membranes of brain cells.* Animal models have shown that citicoline supports learning and memory performance.* Human research indicates citicoline may also improve memory and cognitive function.* (32)

Acetyl-L-carnitine
Carnitine is an amino acid derivative. The acetyl-L form of carnitine is structurally similar to acetylcholine, an important neurotransmitter in the brain, and imitates some of its actions.* Several double-blind, placebo-controlled human clinical trials have shown that acetyl-L-carnitine benefits the brain, with supplementation positively affecting behavior, memory, attention, verbal fluency and logical intelligence.* (33,34,35,36,37) Virutally all of the research executed to date on carnitine and brain health has been performed with the acetyl-L-carnitine form.

Phosphatidylserine
Phosphatidylserine belongs to a class of substances called phospholipids, which are important fatty components of cell membranes. Phosphatidylserine’s major uses include the support of healthy cognitive function and the reduction of occasional stress and moodiness.* (38) Several placebo-controlled studies have shown that cognitive ability was improved significantly with phosphatidylserine supplementation.* (39,40,41,42,43)

Huperzine A
Huperzine A is a phyto-nutrient derived from the club moss Huperzia serrata. Huperzine A supplementation has been shown to support healthy cognitive function and memory in elderly adults.* (44,45,46) In one double-blind placebo-controlled study, huperzine A supplementation also enhanced memory and learning performance in adolescent students.* (47)

Nicotinamide adenine dinucleotide

Nicotinamide adenine dinucleotide (NADH) is an important coenzyme found in all living cells. NADH can support the body’s natural production of neurotransmitters, enabling it to maintain healthy cognitive function.* In a pilot human clinical trial, as well as a randomized, double-blind human study, NADH demonstrated positive effects on cognitive ability, such as supporting verbal fluency and visual-constructional ability.* (48,49)

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