Developed based on a thorough review of the scientific evidence, NutraOrigin's Inflarex formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The information below will give you a detailed understanding of how Inflarex works to diminish occasional pain and inflammation safely and effectively.*

Turmeric Extract
Turmeric, also known Curcuma longa, is a tropical plant native to India and Southeast Asia. It is part of the ginger family. Turmeric's active constituent, curcumin, has been the subject of much scientific research.

A powerful antioxidant, curcumin is recognized for its ability to alleviate occasional inflammation.* (1,2,3) A recent study in patients who had just undergone surgery found that turmeric supported the body's natural response to post-operative inflammation better than placebo.* (2) Animal and human research has shown that turmeric provides comfort to the joints, with one study showing participants experienced improvements in flexibility and walking ability.* (4,5,6)

Bromelain
Bromelain (bromelin) is a collection of proteolytic (protein-digesting) enzymes naturally present in pineapple. Unlike most enzymes, which are broken down in the digestive tract, bromelain appears to be absorbed whole. That could explain why this particular enzyme may have system-wide effects that go beyond its digestive benefits.* (7,8,9)

In a study on healthy adults experiencing acute pain, bromelain relieved discomfort, improved flexibility and physical function, and promoted psychological well-being.* (10) A review study, which analyzed previous studies on bromelain and the health of the knee joint, found evidence of benefit, with eight out of the ten trials showing positive results.* (11) Other research indicates bromelain may accelerate the healing of wounds, burns and minor injuries.* (12,13,14)

Bromelain works by helping the body naturally block metabolites that accelerate and worsen inflammatory processes.*

Boswellia
Boswellia is a gum resin extracted from Boswellia serrata, a tree native to arid, mountainous regions of India. Also known as Indian frankincense, boswellia has been used for centuries in traditional Ayurvedic medicine.

Several double-blind, placebo-controlled human studies have indicated that boswellia helps relieve minor inflammation.* One trial found that taking boswellia for eight weeks significantly contributed to joint comfort, improved knee flexion and increased walking distance compared to placebo.* (15) Another reported that boswellia supported free and easy breathing, with 70 percent of study subjects responding to the herb, compared to just 27 percent who responded to placebo.* (16)

Laboratory research indicates it works by inhibiting the pro-inflammatory enzymes 5-lipoxygenase and human leukocyte elastase.* (17,18,19,20)

Devil's Claw
Devil's claw is a plant native to South Africa. It has traditionally been used to relieve occasional pain and stimulate digestion.*

Devi's claw appears to relieve occasional muscle pain and tension.* A double-blind, placebo-controlled human study found that supplementation with devil's claw for four weeks had a highly significant clinical effect in reducing slight muscular pain of the back, shoulder and neck.* (21) Preliminary evidence indicates devil's claw may also support joint health.* Several human studies have found it reduces joint discomfort and improves mobility.* (22,23,24)

Laboratory research suggests devil's claw works by suppressing the pro-inflammatory enzymes cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS).* (25)

Superoxide Dismutase (SOD) and Catalase
Superoxide dismutase (SOD) and catalyse both play a role in the body's natural antioxidant defense system.* That is important, because free radicals cause oxidation, and oxidation causes inflammation. By increasing the amount of antioxidants in the body, it may be possible to modulate inflammatory pathways that cause occasional pain.* In fact, preliminary animal and human research indicates SOD may support a healthy response to inflammation.* (26,27)

SOD is one of the body's endogenous (self-manufactured) antioxidants. It transforms dangerous superoxide free radicals into the less reactive hydrogen peroxide. Catalase, a second enzyme, then transforms hydrogen peroxide into harmless water and oxygen.* In fact, each second, one molecule of catalase can convert millions of molecules of hydrogen peroxide into water and oxygen. (34) Together, SOD and catalase play a critical role in defending cells against the damaging effects of oxygen radicals.*

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