Developed based on a thorough review of the scientific evidence, NutraOrigin’s Detoxigin formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how Detoxigin supports your body’s ability to rid itself of harmful toxins.*

Artichoke Leaf Extract
Artichoke (Cynara scolymus) leaves have been used traditionally to protect liver health and to increase bile flow, which may help the liver to excrete toxins.* (1,2,3) The herb’s bile-increasing action has been confirmed through in vitro research. (2) Artichoke also appears to have antioxidant properties that protect the body from harmful free radicals.* (4)

Extracts of artichoke leaf have been shown to support a healthy gastrointestinal system.* Several human clinical trials, including one multi-center, double-blind, placebo-controlled study, have found that artichoke extract helps relieve symptoms of indigestion and improves quality of life.* (5,6,7) It was also shown to normalize elimination in one of the studies, reducing the incidence of diarrhea and constipation.* (7)

Milk Thistle Extract
Milk thistle (Silybum marianum) is one of the most researched and best understood medicinal herbs. While a plethora of research has been published on milk thistle in the past 30 years, its use as a liver-protecting herb dates back as far as Pliny the Elder, a first-century Roman physician.* (8)

Numerous controlled human clinical trials have confirmed that milk thistle has powerful liver-protecting abilities.* (8,9,10) Crude milk thistle herb has been approved by the German Commission E, a government regulatory agency that evaluates the safety and efficacy of herbs, for treating indigestion, while preparations of the herb standardized to contain at least 70% silymarin have been approved for detoxifying the liver.* According to the German Commission E monograph on milk thistle, it works by preventing toxins from penetrating the cell membranes of liver cells and encouraging the formation of new liver cells.* (9)

Dandelion Root Extract
Dandelion (Taraxacum officinale), a common weed that grows throughout the United States, has traditionally been used to support liver, gallbladder and kidney health.* (11) It has a reputation for being a blood cleanser and may promote detoxification.*

Constituents found in dandelion root promote bile flow, which helps the body’s ability to detoxify the liver.* (11,12) In fact, it has traditionally been recommended to increase bile flow in people who consume excessive alcohol or eat a poor diet.* (11) Dandelion has also been shown to increase the activity of the phase II detoxification enzyme UDP-glucuronosyl transferase in an animal model.* (11)

Bladder wrack
Fucus vesiculosus, or bladder wrack, is a seaweed and source of the essential mineral iodine. Bladder wrack contains detoxification enzyme systems that allow it to absorb and metabolize toxic polycyclic aromatic hydrocarbons from its aquatic environment.* (13) The naturally occurring polysaccharides in bladder wrack may also have antioxidant activity, potentially providing protection to the body against free radicals.* (14) Test tube and animal studies have shown this variety of seaweed supports normal blood coagulation.* (15)

Burdock Root Extract
Arctium lappa, also known as burdock, is a plant native to Europe and Asia. Herbalists consider burdock to be a powerful blood-purifying agent, which is why it often recommended to help clear the skin of occasional blemishes.* (16,17,18,19)

In an animal study, burdock promoted a healthy response to inflammation and protected the liver from a toxin that had been administered to them.* It also demonstrated free radical scavenging ability against superoxide and hydroxyl radicals.* The researchers suspect this antioxidant activity could explain its inflammation and liver-protective actions.* (20)

Chlorella
Chlorella is a type of single-celled green algae that grows in fresh water. It has a reputation for being a premier detoxifying agent and at least two human clinical trials support that notion.

Japanese researchers conducted two studies on pregnant women to determine if chlorella supplements could lower their levels of toxic dioxins. In each study, the women were divided into two groups: one which received chlorella supplements during pregnancy and the other which acted as controls. Both studies found that chlorella significantly reduced the dioxin level of the women’s breast milk.* (21,22) Additionally, one of the studies found chlorella also had an immune-enhancing effect.* (22)

Green Tea Extract
Green Tea (Camellia sinensis) is made from the same plant as black tea, Camellia sinensis; however, because it is less processed, it retains higher levels of active constituents.

The compounds in green tea increase enzymatic activities in both phase I and phase II detoxification pathways of the liver.* (23) A human clinical trial found that a green tea concentrate, which was high in antioxidant catechins, boosted the subjects’ production of the detoxifying enzyme glutathione S-transferase by as much as 80%.* (24) GST enzymes convert toxins into harmless chemicals.

Rosemary Extract
Rosemary is a common kitchen herb but it is also a well-documented antioxidant.

According to an animal study conducted by French scientists from the National Institute of Agronomic Research in Dijon, rosemary extract enhances levels of detoxifying enzymes in the liver.* (25) It has been shown to increase urine flow in an animal model, which may aid with the faster release of toxins.* (26) Rosemary contains two potent antioxidant agents: caffeic acid and rosmarinic acid.* (27)

Schisandra Extract
Schisandra, also known as magnolia vine, is a treasured liver-protective herb in Traditional Chinese Medicine (TCM). It is categorized as an adaptogen, meaning it can help the body adapt to all kinds of environmental stressors.*

Research has shown that schisandra increases the activity of phase I and phase II detoxification enzymes.* (28) An active constituent of schisandra, called gomisin A, has been identified. In an animal model, gomisin A maintained bile flow and biliary output of electrolytes even in the presence of chemicals toxic to the liver.* (29) Gomisin A has also been shown to stimulate the growth of new liver cells.* (30)

Turmeric Extract
Turmeric, also known Curcuma longa, is a tropical plant native to India and Southeast Asia. It is part of the ginger family. For 4,000 years, turmeric has been used to tonify the stomach and liver and to purify the blood.* (31)

Turmeric increases the secretion of bile, pancreatic and gastric juices, which may help with the elimination of toxins.* (32) The active constituent of turmeric, curcumin, acts as a free radical scavenger.* (32) In addition to its antioxidant activity, curcumin is also recognized for its ability to support a healthy response to inflammation.* (33,34,35)

Yellow Dock Root
Yellow dock (Rumex crispus) is a common weed native to Europe and Asia that is commonly used as a blood and liver purifier. It has been described as a cholagogue to increase bile flow for liver detoxification, as an alterative to restore normal functioning and as a nutritive agent to nourish the body.* Yellow dock is also used to treat indigestion, support the liver and clear the skin.* (35)

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