Developed based on a thorough review of the scientific evidence, NutraOrigin’s Estroese formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how Estroese works to promote estrogen metabolism and protect estrogen-sensitive tissues.*
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Diindolylmethane
Diindolylmethane (DIM) is a naturally occurring phytochemical formed when certain compounds in cruciferous vegetables such as broccoli, Brussels sprouts and cabbage are broken down. The subject of research at UC Berkeley for more than two decades, DIM is currently under study by a major U.S. government research agency for its effect on human health.
When estrogen is metabolized by the body, it can be turned into two possible metabolites: 16alpha-hydroxylated estrogen metabolites, which are biologically strong and therefore pose a health risk, or 2-hydroxylated metabolites, which are relatively weak and therefore harmless. The ratio of 2-OHE1 to 16alpha-OHE1 is one measure used to evaluate a person’s health status. (1)
A double-blind human pilot study on DIM conducted by UC Berkeley researchers found that taking DIM shifts the conversion of estrogen away from the unwanted 16alpha-OHE1 variety and toward the desirable 2-OHE1.* In fact, women who took DIM experienced a 47% increase in their 2-OHE1 to 16alpha-OHE1 ratio.* (2)
Rosemary Leaf Extract
Rosemary (Rosmarinus officinalis), a fragrant perennial herb native to the Mediterranean, is used typically as a seasoning. However, this kitchen herb has powerful biological effects.
Rosemary extract has been demonstrated in an animal model to stimulate the beneficial 2-hydroxylation of estrogen and inhibit the undesired 16-hydroxylation of the hormone.* (3) As a standardized extract, it may also enhance the conjugative metabolism of estrogen, a process by which estrogen is joined with another compound (in this case glucuronide) that detoxifies it and supports its efficient elimination from the body.* (3)
Lecithin
Lecithin is a phospholipid, or a phosphorous-containing fat, that is a main component of cell membranes. It is a natural source of choline and inositol, two B vitamin-like compounds.
One little-known function of lecithin is that it helps fats move in and out of liver cells, so it is essential for healthy liver function.* (4) Since the liver is responsible for detoxifying estrogen, impaired liver function could result in excess estrogen. Lecithin promotes the flow of bile, which could hypothetically help the body in eliminating estrogen from the system.* (5)
Quercetin
Quercetin (3,3'4',5,7-pentahydroxy flavone) is an antioxidant that forms naturally when glucobrassicin, a phytochemical found in cruciferous vegetables, is broken down.
Quercetin is a phytoestrogen (plant estrogen), meaning it is similar in structure to human estrogen and can compete with it for absorption.* Laboratory research has demonstrated that quercetin binds to estrogen-receptor sites located on human cells, and thus exhibits anti-estrogenic effects.* (6)
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- Muti P, et al. "Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16alpha-hydroxyestrone ratio in premenopausal and postmenopausal women." Epidemiology (2000) Nov;11(6):635-40.
- Dalessandri KM, et al. "Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer." Journal of Nutrition and Cancer (2004);50(2):161-7.
- Zhu B.T., et al. "Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice." Carcinogenesis (1998) 19(10): 1821-27.
- Wojcicki, J. et al. "Clinical evaluation of lecithin as a lipid-lowering agent." Phytotherapy Research (1995);9: 579-97.
- Ronald Hoffman, M.D, "Estrogen Dominance Syndrome." http://www.drhoffman.com/page.cfm/183
- Scambia G, et al. "Quercetin induces type-II estrogen-binding sites in estrogen-receptor-negative (MDA-MB231) and estrogen-receptor-positive (MCF-7) human breast-cancer cell lines." Int J Cancer (1993) May 28; 54(3): 462-6.
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