Developed based on a thorough review of the scientific evidence, NutraOrigin's Vizarex formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how this Vizarex works to maintain healthy eyes and clear vision.*
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Antioxidant Vitamins and Minerals
Antioxidants such as beta carotene, vitamin C, vitamin E and zinc may protect the macula of the eye from free radical damage.* A landmark randomized, double-blind, placebo-controlled human clinical trial, known as AREDS, tested the effects of four treatments in over 3,000 individuals: 1. Antioxidants alone (beta carotene, vitamin C and vitamin E), 2. Zinc and copper alone, 3. Antioxidants plus zinc and copper, or 4.) Placebo. After six years of follow-up, it was determined that, compared to placebo, the antioxidants plus zinc and copper combination caused statistically significant improvements in eye health and visual acuity.* (1) Other research has confirmed that people who have a high dietary intake of beta carotene, vitamin C, vitamin E and zinc are more likely to enjoy ocular health.* (2)
Selenium is another mineral antioxidant. Within the lens of the eye, selenium is required for the formation of glutathione peroxidase - one of the body's most important antioxidants.* Research has shown that people who enjoy good vision tend to have higher levels of selenium within the serum and aqueous humor of their eyes.* (3)
Antioxidant Carotenoids
Carotenoids, including astaxanthin, lutein, lycopene and zeaxanthin are natural plant pigments that have free radical scavenging capacity.* They give some foods their autumnal hues. For example, lycopene makes tomatoes bright red, lutein imparts a yellowish-orange color to mangoes, corn and squash, and astaxanthin makes salmon pink.
Both lutein and zeaxanthin are known to accumulate in the macular region of the retina, where they act as a sort of internal sunscreen, filtering out damaging UV light.* (4) Researchers at Harvard University have observed that people who ingest high amounts of lutein and zeaxanthin through the diet are significantly more likely to maintain healthy vision than those who eat very little of these protective carotenoids.* (5) Two double-blind, placebo-controlled human clinical trials have confirmed that lutein protects visual function.* (6,7)
One observational study has also shown a correlation between increased lycopene consumption and better eye health.* (8) Initial laboratory research indicates astaxanthin may protect the lens of the eye from oxidative damage.* (9)
Bilberry Extract
A small round fruit, bilberry is a relative of blueberries, cranberries and huckleberries. It has been used to promote visual acuity ever since British Royal Air Force pilots flying during World War II reported that eating bilberry jam improved their night vision.*
A small open-label human study found that anthocyanosides - antioxidant phyto-nutrients found in bilberry - positively impact the permeability of the retinal blood vessels.* (10) This finding is supported by laboratory research showing that anthocyanosides strengthen the capillary walls.* (11)
Black Currant Extract
Like bilberry, black currant extract is a concentrated source of antioxidant anthocyanosides.
A small double-blind, placebo-controlled human clinical trial found that black currant polyphenols improved night vision in healthy human subjects.* (12) Another double-blind, placebo-controlled human study found that a combination of lutein, zeaxanthin and black currant extract improved visual fatigue.* (13)
Grape Seed Extract
Grape seed extract is extremely high in proanthocyanidins, which are formed from a group of molecules known as flavonoids or bioflavonoids. Proanthyocyanidins, also known as OPCs, are among the most beneficial of all antioxidants.
A human clinical trial enrolling 100 subjects found that OPCs from grape seed extract improved visual performance after being exposed to glare and helped the eyes adapt to conditions of low light compared to control.* (14)
Green Tea Extract
Green Tea (Camellia sinensis) is made from the same plant as black tea; however, because it is less processed, it retains higher levels of active constituents. The main antioxidants contained within green tea are catechin polyphenols, and scientists have paid particular attention to a constituent called epigallocatechin gallate (EGCG). A recent USDA tea study noted that among all the catechins, EGCG was the most potent by a wide margin.
Although green tea has not yet been tested in a human clinical trial for its effect on eye health, laboratory and animal research looks very promising. Catechins from green tea, especially EGCG, have been shown to protect the retina from damage caused by free radicals, light and toxins.* (15-21) Green tea extract has also been demonstrated to preserve the clarity of the lens of the eye.* (22-24)
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- Age-Related Eye Disease Study Research Group. "A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS Report no.8." Arch Ophthalmol (2001) 119:1417-1436.
- Van Leeuwen R, et al. "Dietary intake of antioxidants and risk of age-related macular degeneration." JAMA (2005) Dec;294(24):3101-3107.
- Karakucuk S, et al. "Selenium concentrations in serum, lens, and aqueous humor of patients with senile cataract." Acta Ophthalmol Scand (1995) Aug;73(4):329-32.
- Bone RA, Landrum JT. "Distribution of macular pigment components, zeaxanthin and lutein, in human retina." Methods Enzymol (1992) 213:360-6.
- Seddon JM, et al. "Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration." JAMA (1994) 272:1413-20.
- Richer S, et al. "Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)." Optometry (2004) 75:216-30.
- Olmedilla B, et al. "Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study." Nutrition (2003) 19:21-24.
- Mares-Perlman JA, et al. "Serum antioxidants and age-related macular degeneration in a population-based case-control study." Arch Ophthalmol (1995) Dec;113(12):1518-23.
- Wu TH, et al. "Astaxanthin protects against oxidative stress and calcium-induced porcine lens protein degradation." J Agric Food Chem (2006) Mar 22;54(6):2418-23.
- Mian E, et al. "Anthocyanosides and the walls of the microvessels: further aspects of the mechanism of action of their protective effect in syndromes due to abnormal capillary fragility [in Italian; English abstract]." Minerva Med (1977) 68:3565-3581.Close window
- Scharrer A, Ober M. "Anthocyanosides in the treatment of retinopathies." Klin Monbl Augenheilkd. (1981) May;178(5):386-9.
- Nakaishi H, et al. "Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans." Altern Med Rev (2000) Dec;5(6):553-62.
- Yagi A, et al. "The effect of lutein supplementation on visual fatigue: A psychophysiological analysis." Appl Ergon (2009) Nov;40(6):1047-54.
- Corbe C, Boissin JP, Siou A. "Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers [translated from French]." J Fr Ophtalmol (1988) 11:453-460.
- Zhang B, et al. "Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion." Brain Res (2007) Jul 23;1159:40-53.
- Zhang B, Osborne NN. "Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate." Brain Res (2006) Dec 8;1124(1):176-87.
- Fan B, et al. "Neuroprotective effect of epigallocatechin gallate on oxidative-stress-injured retinal cells." Zhonghua Yi Xue Za Zhi (2008) Jun 24;88(24):1711-4.
- Chan CM, et al. "Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells." Mol Vis (2008) 14:2528-34.
- Zhang B, Rusciano D, Osborne NN. "Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro." Brain Res (2008) Mar 10;1198:141-52.
- Costa BL, et al. "Orally administered epigallocatechin gallate attenuates light-induced photoreceptor damage." Brain Res Bull (2008) Jul 1;76(4):412-23.Close window
- Siu AW, et al. "Glutamate-induced retinal lipid and protein damage: the protective effects of catechin." Neurosci Lett (2008) Feb 27;432(3):193-7.
- Thiagarajan G, et al. "Antioxidant properties of green and black tea, and their potential ability to retard the progression of eye lens cataract." Exp Eye Res (2001) Sep;73(3):393-401.
- Vinson JA, Zhang J. "Black and green teas equally inhibit diabetic cataracts in a streptozotocin-induced rat model of diabetes." J Agric Food Chem (2005) May 4;53(9):3710-3.
- Gupta SK, et al. "Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis." Ophthalmic Res (2002) Jul-Aug;34(4):258-63.
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