Developed based on a thorough review of the scientific evidence, NutraOrigin's Nufolex formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how Nufolex works to reduce hair loss associated with aging.*

Saw Palmetto Berry Extract and Pygeum Extract
Saw palmetto (Serenoa repens) and pygeum are well-established to promote prostate health, and they may reduce age-associated hair loss by the same mechanism.*

One randomized, double-blind, placebo-controlled pilot study of 19 men yielded promising results. Participants took either a saw palmetto plus beta-sitosterol supplement or a placebo. Thei hair was evaluated by an investigative staff at baseline and again four and a half months later. At the end of the study, 60% of men in the saw palmetto group were rated as "improved," compared to just 11% in the placebo group.* (1) Due to the small sample size, the results were not statistically significant, but they do establish the need for a larger clinical trial. It is believed that saw palmetto inhibits the enzyme that converts testosterone into the undesirable dihydrotestosterone.* (1)

While no human studies have been conducted to date on pygeum and hair loss due to normal aging, laboratory research has shown that the herb binds to human androgen receptors.* (2) By blocking the uptake of testosterone, pygeum could theoretically prevent its conversion to dihydrotestosterone.* However, more research is needed to confirm this theory.

Burdock Root
Arctium lappa, also known as burdock, is a plant native to Europe and Asia. Herbalists consider burdock to be a powerful blood-purifying agent.*

Burdock root has traditionally been used to prevent hair loss associated with the normal aging process.* (3) Animal research indicates burdock supports a healthy response to inflammation, which may be important, as inflammation of the hair follicle could be a factor in age-related hair loss.* (4,5)

Ginkgo Leaf Extract
Hair loss that naturally accompanies aging may be due in part to microvascular insufficiency - i.e. a lack of circulation to the body's extremely small blood vessels, such as those in the scalp. If a root does not get enough blood, oxygen and nutrients, it may die and fall out.

Ginkgo biloba is a Chinese herb that has been shown to increase blood circulation, which may support a healthy scalp and healthy hair.* (6,7,8)

Green Tea Extract
Green Tea (Camellia sinensis) is made from the same plant as black tea; however, because it is less processed, it retains higher levels of active constituents. The main antioxidants contained within green tea are catechin polyphenols, and scientists have paid particular attention to a constituent called epigallocatechin gallate (EGCG). A recent USDA tea study noted that among all the catechins, EGCG was the most potent by a wide margin.

According to animal research, polyphenolic compounds in green tea leaf extract support healthy hair growth.* (9) A laboratory study found that EGCG promoted hair growth in human hair follicles ex vivo and stimulated the growth of dermal papilla cells in vitro.* (10) Ginkgo appears to work by inhibiting the enzyme that converts testosterone into dihydroxytestosterone.* (10)

Stinging Nettle Root Extract and Horsetail Extract
Stinging nettle (Urtica dioica) and horsetail (Equisetum arvense) have traditionally been used to reduce hair loss associated with aging and may strengthen new and existing hair.* (11,12,13)

Both herbs are valued for their high content of naturally occurring minerals and antioxidants. Nettle contains up to 20% minerals - including calcium, potassium and silicon - and is also rich in antioxidants such as flavonoids, vitamin C, beta carotene and vitamin E. Horsetail contains large amounts of silica, cysteine and sulfur, as well as flavonoids and phenolic acids. As such, these herbs act as nourishing tonics, providing the nutrition needed to grow healthy hair.*

Methylsulfonylmethane
Keratin, a strong, fibrous protein, is the main structural component of hair. It is made up of amino acids such as glycine, alanine and the sulfur-containing cysteine. Therefore, healthy hair depends on adequate amounts of sulfur.

Methylsulfonylmethane (MSM) is a sulfur-containing compound that naturally occurs in the food supply. It is used to help maintain normal keratin levels in hair, skin and nails.*

Pyridoxal-5'-phosphate
Pyridoxal-5'-phosphate (P5P) is the active form of vitamin B6. Because vitamin B6 plays a role in amino acid metabolism, it is needed for the proper growth of all parts of the body, including the hair.*

Studies in animals and humans indicate vitamin B6 may support hair growth.* (14,15) It has been shown in a laboratory model to potentiate zinc's ability to inhibit the enzyme that converts testosterone into dihydroxytestosterone.* (16) Pyridoxal-5'-phosphate (P5P) appears to be better absorbed in some individuals than the commonly used form of vitamin B6 (pyridoxine). (17)

Zinc
The trace element zinc is one of the essential minerals in the human diet. Zinc deficiency, while uncommon, can result in hair loss.* (18)

In an animal model, zinc was shown to accelerate hair re-growth caused by chemically induced hair loss.* (19) A human study found that high-dose zinc therapy (200 mg, three times a day) arrested hair loss due to zinc deficiency and promoted hair re-growth.* (20) Laboratory research indicates that zinc works by limiting the conversion of testosterone into dihydroxytestosterone.* (16)

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