Developed based on a thorough review of the scientific evidence, NutraOrigin’s Migranalief formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how this product works relieve occasional headache pain.*

Butterbur Root
The butterbur plant (Petasites hybridus) is a shrub found in Europe, Asia and North America. It has been used for over 2,000 for a variety of conditions.

Two placebo-controlled human clinical trials found butterbur extract is effective for reducing the frequency of occasional headaches.* The first study reported that butterbur decreased headache frequency by a maximum of 60% compared to pre-treatment.* (1) The authors concluded the herb had high efficacy and excellent tolerance. The second study showed that butterbur caused a 48% reduction in headache frequency and that two-thirds of study subjects experienced significant benefit.* (2)

Both studies used extracts of butterbur standardized for petasin - the active constituent. Migranalief provides 225 mg of butterbur per daily dose, standardized to 15% petasin.

Feverfew Extract
Native to southeastern Europe, feverfew (Tanacetum parthenium) has been used for hundreds of years in traditional European herbalism to relieve occasional headache pain.*

Three double-blind, placebo-controlled clinical trials on feverfew have confirmed the herb's traditional use.* The results of these studies indicate that feverfew extract caused a significant reduction in both the frequency and severity of occasional headaches.* (3,4,5) * One of the trials found feverfew reduced headache frequency by 24%, while another showed an even more profound reduction of 40%. (3,4)

Feverfew is believed to work by relieving smooth muscle spasms and preventing blood vessel constriction.* (6)

Ginger Extract
Ginger is the rhizome of the perennial plant Zingiber officinale in the family Zingiberaceae. It is one of the only herbs that is included in three of the major schools of traditional herbalism: Traditional Chinese Medicine, Ayurveda and traditional European herbalism.

Some headaches may be caused by an increased release of inflammatory mediators. Ginger has been shown to support a healthy response to inflammation,(7) thus it may help relieve occasional headache pain.*

5-Hydroxytryptophan
It has been established that low levels of the neurotransmitter serotonin sometimes accompany occasional headaches. One of serotonin's jobs is to control the sensation of pain. Therefore, increasing levels of serotonin should alleviate headache pain.

5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid that is a precursor to serotonin. Several well-controlled clinical trials have found that 5-HTP reduces the frequency, intensity and/or duration of occasional headaches in both adults and children.* (8,9,10,11,12) It also improves sleep quality.* (12)

CoQ10
Coenzyme Q10, also known as ubiquinone, is a fat-soluble vitamin-like substance that is present in most human cells and that participates in the body's production of energy.*

A double-blind, randomized, placebo-controlled clinical trial of 42 people found that CoQ10 supplementation reduced the frequency of occasional headache.* It cut headache frequency in half for nearly 50% of subjects - more than three times the efficacy rate of placebo.* (13)

Riboflavin
Researchers believe that some headaches may be due to a deficit in mitochondrial energy production. Riboflavin, also known as vitamin B2, is an easily absorbed micronutrient that plays an important role in the production of energy.*

A randomized, placebo-controlled human clinical trial found that riboflavin was able to reduce the frequency of occasional headache.* It had a similar efficacy rate to CoQ10 in this regard, cutting headache frequency in half for 59% of subjects, compared to just 15% for placebo.* (14)

Turmeric Extract
Turmeric, also known Curcuma longa, is a tropical plant native to India and Southeast Asia. It is part of the ginger family.

Some headaches may be caused by an increased release of inflammatory mediators. Turmeric has been shown to support a healthy response to inflammation,(15,16,17) which means it may help alleviate occasional headache pain.*

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