Developed based on a thorough review of the scientific evidence, NutraOrigin’s Cytogin formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how Cytogin protects your cells — and yourself — from the ravages of free radicals.*
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Ashwagandha
Ashwaganda is an Indian herb that plays a central role in the herbal tradition of Ayurveda. It is a highly versatile ingredient with many benefits:
- Has powerful antioxidant properties* (1)
- Is an adaptogen, a rare class of herbs that help the body adapt to stress* (2)
- Is protective and tonifying* (3)
- Protects immune function* (4,5,6,7)
- Supports healthy blood markers, including hemoglobin concentration, red blood cell count and white blood cell count* (6)
- Supports a healthy response to inflammation* (8,9)
Grape Seed Extract
Grape seed extract is extremely high in proanthocyanidins, which are formed from a group of molecules known as flavonoids or bioflavonoids. Proanthyocyanidins are among the most beneficial of all antioxidants.* (10,11)
Grape seed extract has demonstrated numerous health benefits in human clinical trials, including preventing the oxidation of low-density lipoprotein (LDL) cholesterol,* (12) promoting youthful-looking skin* (13,14) and maintaining blood pressure and cholesterol levels already within a healthy range.* (15,16)
Green Tea Extract
Green Tea (Camellia sinensis) is made from the same plant as black tea; however, because it is less processed, it retains higher levels of active constituents. The main antioxidants contained within green tea are catechin polyphenols, and scientists have paid particular attention to a constituent called epigallocatechin gallate (EGCG). A recent USDA tea study noted that among all the catechins, EGCG was the most potent by a wide margin.*
Modern research has revealed several benefits of green tea. A double-blind controlled study found that subjects ingesting a high-catechin green tea beverage had a significantly greater decrease in waist circumference than those drinking a low-catechin version.* (17) Another human clinical trial, which pitted green tea capsules against placebo in 111 healthy volunteers, found the green tea caps maintained blood pressure and cholesterol that was already within a healthy range, reduced oxidative stress and supported a healthy response to inflammation.* (18) Green tea has also been shown to protect LDL cholesterol from oxidation,* (19, 20) benefit endothelial function,* (21) increase fat oxidation in overweight individuals* (22, 23) and improve antioxidant status.* (24)
Lycopene
The phytochemical lycopene is what gives tomatoes, watermelon, guava and pink grapefruit their pink and red hues. A powerful antioxidant, lycopene fights free radicals and acts as an important nutritional accessory in protecting against the damaging effects of sunlight and oxygen.* It is especially efficient at quenching a particularly nasty free radical called singlet oxygen.* (25)
Observational studies indicate that lycopene may preserve the health of the eyes and protect cardiovascular health.* (26,27,28) However, lycopene is probably most well-known for its role in supporting prostate health.* (29,30,31)
Turmeric Extract
Turmeric, also known Curcuma longa, is a tropical plant native to India and Southeast Asia. It is part of the ginger family. Turmeric’s active constituent, curcumin, has been the subject of much scientific research.*
Curcumin acts as a free radical scavenger.* (32) It inhibits harmful oxidation — including the oxidation of LDL cholesterol — and can protect polyunsaturated fatty acids from damage induced by radical molecules.* (33) In addition to its antioxidant activity, curcumin is also recognized for its ability to support a healthy response to inflammation.* (34,35,36)
Pomegranate Extract
Pomegranate extract abounds with polyphenols called punicalagins, which have powerful free radical scavenging properties.* When punicalagins are hydrolyzed during metabolism, they create ellagic acid, which has been the subject of much scientific scrutiny for its ability to provide protection to the cells.* (37) Punicalagins are absorbed by the body and have dietary value as antioxidants.* (38) However, punicalagins are just one of the antioxidants present in pomegranate; it also contains vitamin C, beta-carotene, catechins and anthocyanins.*
Pomegranate has been shown to support a healthy response to inflammation in an animal model.* (39) At least one human clinical trial has found that pomegranate juice supports prostate health.* (40) Other human studies have found pomegranate juice improves circulation to the heart,(41) maintains blood pressure already within a healthy range and supports healthy arteries.* (42)
Vitamin C
Vitamin C (ascorbic acid) has remained one of the most beneficial and most widely consumed vitamins for a century. It is a water-soluble antioxidant, meaning it protects the aqueous portion of cells from free radicals.* Vitamin C may have the ability to regenerate, or bring back to life, other antioxidants such as vitamin E.* (43)
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- Bhattacharya A, Ghosal S, Bhattacharya SK. "Antioxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum." J Ethnopharmacol. 2001 Jan;74(1):1-6.
- Dadkar VN, Ranadive NU, Dhar HL. "Evaluation of antistress (adaptogen) activity of Withania somnifera (ashwagandha)." Indian J Clin Biochem . 1987;2:101-108.
- Thatte UM, Chhabria SN, Karandikar SM, Dahanukar SA. "Protective effects of Indian medical plants against cyclophosphamide neutropenia." J Postgrad Med 1987;33:185
- Ghosal S, Lal R, Srivastava SK, et al: "Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera." Phytother Res 1989;3:201-206.
- Dhuley JN. "Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice." J Ethnopharmacol 1997 Sep;58(1):15-20.
- Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. "Studies on immunomodulatory effects of Ashwagandha." J Ethnopharmacol ( 1996;) 50:: 69-76.
- Singh N, Singh SP, Nath R, et al. "Prevention of urethane-induced lung adenomas by Withania somnifera (L.) Dunal in albino mice." Int J Crude Drug Res 1986;24:90-100.
- Anbalagan, K. and J. Sadique "Withania somnifera (Ashwagandha), a rejuvenating herbal drug which controls alpha-2-macroglobulin synthesis during inflammation." International Journal Of Crude Drug Research. 1985;23(4): 177-183.
- Al-Hindawi MK, al-Khafaji SH, Abdul-Nabi MH. "Anti-granuloma activity of Iraqi Withania somnifera ." J Ethnopharmacol . 1992;37:113-116.
- Grape seed Extract." PDRHealth, www.pdrhealth.com (2005) February.Close window
- "Grape seed Extract." PDRHealth, www.wholehealthmd.com (2005) February.
- Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Dreuss HG, Vinson JA. "Molecular mechanism of cardioprotection by a novel grape seed proanthocyanidin extract." Mutat Res (2003) Feb-Mar; 523-524: 87-97.
- Hughes-Formella B, Wunderlich O, Williams R. "Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins." Skin Pharmacol Physiol. 2007;20(1):43-9.
- Yamakoshi J, et al. "Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma." Phytother Res. 2004 Nov;18(11):895-9.
- Sivaprakasapillai B, et al. "Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome." Metabolism. 2009 Dec;58(12):1743-6.
- Kar P, et al. "Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009 May;26(5):526-31.
- Agao T, et al. "A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes." Obesity (Silver Spring). 2009 Feb;17(2):310-7.
- Nantz MP, et al. "Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study." Nutrition. 2009 Feb;25(2):147-54.
- Gomikawa S, et al. "Effect of ground green tea drinking for 2 weeks on the susceptibility of plasma and LDL to the oxidation ex vivo in healthy volunteers." Kobe J Med Sci. 2008 May 23;54(1):E62-72.
- Inami S, et al. "Tea catechin consumption reduces circulating oxidized low-density lipoprotein." Int Heart J. 2007 Nov;48(6):725-32.Close window
- Alexopoulos N, et al. "The acute effect of green tea consumption on endothelial function in healthy individuals." Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):300-5.
- Boschmann M, Thielecke F. "The effects of epigallocatechin-3-gallate on thermogenesis and fat oxidation in obese men: a pilot study." J Am Coll Nutr. 2007 Aug;26(4):389S-395S.
- Auvichayapat P, et al. "Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial." Physiol Behav. 2008 Feb 27;93(3):486-91.
- Erba D, et al. "Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans." J Nutr Biochem. 2005 Mar;16(3):144-9.
- Di Mascio P, Kaiser S, Sies H. "Lycopene as the most efficient biological carotenoid singlet oxygen quencher." Arch Biochem Biophys. 1989 Nov 1;274(2):532-8.
- Mares-Perlman JA, Brady WE, Klein R, et al. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol. 1995;113:1518-1523.
- Sesso HD, Liu S, Gaziano JM, et al. Dietary lycopene, tomato-based food products and cardiovascular disease in women. J Nutr. 2003;133:2336-2341.
- Sesso HD, Buring JE, Norkus EP, et al. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr. 2005;81:990-997.
- Kucuk O, Sarkar FH, Sakr W, et al. "Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy." Cancer Epidemiol Biomarkers Prev. (2001) Aug; 10(8): 861-8.
- Kucuk O, et al. "Effects of lycopene supplementation in patients with localized prostate cancer." Exp Biol Med (Maywood). 2002 Nov;227(10):881-5.Close window
- Giovannucci E, et al. "A prospective study of tomato products, lycopene, and prostate cancer risk." J Natl Cancer Inst. 2002 Mar 6;94(5):391-8.
- Sreejayan N, Rao MNA. Free radical scavenging activity of curcuminoids. Arzneimittelforschung.1996;46:169-171.
- Reddy AC, et al. "Effect of Dietary Turmeric (Curcuma longa) on Iron-induced Lipid Peroxidation in the Rat Liver." Food Chem Toxicol (1994) Mar; 32(3): 279-83.
- Ammon HP, Wahl MA. "Pharmacology of Curcuma longa." Planta Med. 1991 Feb;57(1):1-7.
- Satoskar RR, Shah SJ, Shenoy SG. "Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation." Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12)651-4.
- Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcumalonga. Phytomedicine. Jul 2000;7(4):303-8.
- Gross PM. "Exotic antioxidant superfruits - Pomegranate punicalagins: Ancient aril antioxidants." NPI Center. March 30, 2007. http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=18139&zoneid=201
- Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L, Derendorf H. "Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers." J Agric Food Chem (2006) Nov 15; 54(23): 8956-61.
- Meenakshi S, et al. "Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J Inflamm. 2008;5:9.
- Pantuck AJ, et al. "Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer." Clin Cancer Res. 2006 Jul 1;12(13):4018-26.Close window
- Sumner MD, et al. "Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease." Am J Cardiol. 2005 Sep 15;96(6):810-4.
- Basu A, Penugonda K. "Pomegranate juice: a heart-healthy fruit juice." Nutr Rev. 2009 Jan;67(1):49-56.
- Carr AC, Frei B. "Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans." Am J Clin Nutr. 1999;69(6):1086-1107.
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